Endocrine Abstracts

Fatty liver (Hepatic Steatosis) is common in men with type 2 diabetes mellitus (T2DM). Furthermore there is a high prevalence of testosterone deficiency (up to 40%) in this population. Testosterone replacement therapy (TRT) has been shown to reduce elevated serum liver transaminase levels in hypogonadal men. The testicular feminised (Tfm) mouse exhibits a non-functional androgen receptor (AR) and low circulating testosterone levels. We have previously shown that a high-fat die...

Testosterone deficiency is associated with several cardiovascular risk factors. Testosterone replacement therapy (TRT) improves insulin sensitivity, inflammation and cholesterol. Liver X receptor (LXR) is a nuclear receptor which regulates lipid and glucose metabolism, stimulates cholesterol efflux and ApoE, and suppresses inflammation. LXR agonists cause hepatic steatosis but protect against atherosclerosis. TRT attenuates high-cholesterol diet-induced hepatic steatosis in th...

Hypogonadism is highly prevalent in men with type 2 diabetes (T2D) and/or cardiovascular disease (CVD). Low testosterone levels are associated with CVD risk factors including obesity, insulin resistance, dyslipidaemia and hypertension. Testosterone replacement therapy (TRT) has been shown to have beneficial effects on these parameters; however, safety needs to be verified. An audit of 308 (50% with T2D, 32.1% CVD, 82.8% ED) hypogonadal men (age 59.02±13.23 years; mean bas...